Metabolic Cell Changes in ME/CFS

The body responds to illness and injury through changes in metabolism. These changes help the body fight infection and repair tissues.

Sometimes, the metabolic changes that are turned on to defend the body don’t turn off– even after the infection or injury are resolved.

Failure to turn metabolism back to normal may be the cause of ME/CFS.

Five Metabolic Changes that Remain in ME/CFS Patients

A. Chronic Inflammation Activation via the NF-kB Pathway

B. Increased Glycolysis (the Warburg Effect), and Alternative Energy Production in the Cytoplasm instead of the Mitochondria

C. Decreased NAD+/NADH Ratio

D. Mitochondrial Malfunction

E. Reduced Activation of AMPK

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